Nathan Drake is a clever and street smart young man who has always been fascinated by lost treasures and forgotten legends. His life changes when he teams up with the experienced and sarcastic Victor Sully Sullivan for a dangerous hunt for what is believed to be the greatest treasure never discovered. As they follow a series of mysterious clues across different locations, they soon realize that they are not the only ones searching for the legendary fortune. At the same time, Nathan hopes the clues may help him uncover the truth about his long lost brother and finally learn what happened to him. Their journey quickly becomes a race against ruthless enemies, hidden secrets, and deadly traps.